The Neuroinflammation and Loss of Hippocampal GABAergic Interneurons That Mediate Age-Related Decline in Cognitive Function May be Interdependent

This article discusses the neurological mechanisms which are suspected to bring on the cognitive decline associated with healthy aging – in particular, the mild brain inflammation associated with the chronic activation of microglial cells (neuroinflammation), and the die off of certain neurons that produce the neurotransmitter GABA. Practical strategies for mitigating these effects, and hence slowing or prevening age-related cognitive decline, are suggested.

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