Dietary Nitrate and Reductive Polyphenols May Potentiate the Vascular Benefit and Alleviate the Ulcerative Risk of Low-Dose Aspirin

Low-dose aspirin has tremendous protective potential; not only can it reduce risk for heart attack and stroke, but more recent evidence suggests it may notably reduce cancer mortality during long-term use. Nonetheless, it also sometimes provokes GI ulceration and bleeding that in some cases can be life-threatening. This essay proposes that joint consumption of dietary nitrate and of certain natural polyphenols, in foods or supplements, may decrease this bleeding risk by generating protective nitric oxide in the gastric lining – making low-dose aspirin more uniformly protective.

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