High-Salt, Low-Potassium Diets May Increase Risk for Type 2 Diabetes via Marinobufagenin-Mediated Potentiation of Glucolipotoxicity in Pancreatic Beta Cells

A couple of recent Finnish epidemiological studies have yielded that novel conclusion that a high-salt diet may increase risk for type 2 diabetes. This article proposes that high salt intakes in salt-sensitive subjects, by increasing the production of a pro-oxidant factor known as marinobufagenin, may boost oxidative stress in the insulin-production pancreatic beta cells, and that this may help to precipitate the onset of diabetes by impairing beta cell function.

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