Folate Deprivation/Antagonist Therapy for Early Stage Prostate Cancer

Prostate epithelium, and some early prostate cancers, appear to require higher concentrations of folic acid than most other tissues to support a maximal rate of cellular multiplication. Therefore, a low-folate diet and/or low doses of the folate antagonist methotrexate may have the potential to slow the onset and growth of early stage prostate cancer – a possibility that could be tested clinically.

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