High-Dose Statin Flash-Potentiation of Cancer Chemotherapy

Concentrations of statins much higher than those achieved clinically have potentiated the cancer-killling efficacy of many cytotoxic chemotherapeutic agents in cell culture studies or mice, but would be toxic if sustained in humans. This essay proposes that administration of very-high-dose statins for just several days prior to and following a dose of chemotherapy might achieve worthwhile chemopotentiation without unacceptable toxicity, and that this strategy merits clinical evaluation. Concurrent administration of tocotrienols may amplify response to such a regimen.

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