Targeting Adipocytes in Metabolic Syndrome – Spirulina and Salsalate May Complement the Benefits of PPARgamma Agonists

Metabolic syndrome, an important cause of vascular disease and type 2 diabetes, and a risk factor for cancer, is driven by an inflammatory state that arises in overstuffed fat cells (adipocytes). The diabetes drug pioglitazone (Actos) is useful for dampening this adipocyte inflammation and ameliorating metabolic syndrome, but has side effects which limit its broad use. This essay proposes that spirulina and salsalate also have the potential to act directly on adipocytes to quell inflammation, and may complement the utility of pioglitazone in this regard, or be employed as an alternative approach to improving adipocyte function.

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