Phycocyanobilin and Dietary Nitrate May Exert Natriuretic Effects That Suppress Production of Marinobufagenin

There is reason to suspect that both dietary nitrate – found in green leafy vegetables and beets – and the key phytochemical in spirulina, phycocyanobilin (PhyCB), can act on the kidneys to promote more efficient excretion of sodium, owing to their ability to boost the bioactivity of the protective hormone nitric oxide while controlling oxidative stress. This in turn would be expected to lessen adrenal production of marinobufagenin, a hormone suspected to mediate both the increase in blood pressure, and the increased risk or vascular diseases, associated with salt-sensitive hypertension. Nitrate and PhyCB might also act directly on MBG’s target tissues to lessen its pathogenic impact.

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