Practical Strategies for Targeting NF-kappaB and NADPH Oxidase May Improve Survival During Lethal Influenza Epidemics

Perhaps surprisingly, the “killer” influenzas do not kill by the direct damaging impact of the flu virus on lung tissue, but rather by the over-exuberant immune response which such infections can evoke – effectively filling the lungs with fluid. An analysis of the mechanisms responsible for this inflammation leads to the proposal that administration of spirulina, N-acetylcysteine, and the drug salsalate, initiated as soon as possible after the onset of infection, may dampen the evoked inflammation and hence lessen the lethality of “killer” flus.

Published in Medical Hypotheses 2010;74(1):18-20.

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