CK2 Inhibition May be a Key Mediator of the Cancer-Retardant Effects of Natural Flavones in Xenografted Nude Mice

An enzyme known as CK2 is highly active in a high proportion of aggressive cancers, and functions in numerous ways to make cancers more aggressive and harder to kill. Drugs which target this enzyme are currently being developed in hopes that they can become safe and effective therapies for cancer. Certain widely distributed phytonutrients – known as flavones and flavonols – have the potential to inhibit CK2 in concentrations that might conceivably be achieved via oral administration. It is proposed that this phenomenon may account, at least in part, for the demonstrated ability of these compounds to slow the growth of human cancers implanted in mice; hence, these compounds may merit serious clinical evaluation as cancer-retardant agents.

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